When should a complete reinstallation of Windows 10 be considered as the last resort for persistent error 0xc000000e?

A complete reinstallation should be considered as a last resort when all other troubleshooting steps, including automatic repair, manual BCD rebuilds, disk checks, and BIOS/UEFI adjustments, have failed to resolve error 0xc000000e. Before proceeding, ensure you have backed up any critical data from your drives (if accessible, perhaps by connecting the drive to another PC or using a Linux live USB). This step implies that the core operating system files, boot configuration, or even the underlying disk structure are so corrupted that repair is no longer feasible, making a fresh start the most reliable solution.