How does Stephan Pastis use self-referential humor in 'Pearls Before Swine'?

Stephan Pastis frequently employs self-referential humor by having characters comment on the comic strip itself. They'll discuss the limitations of the four-panel format, the need for punchlines, or the absurdity of repeating gags. He even includes 'failed' comic ideas or strips that acknowledge they aren't funny, adding a layer of meta-commentary that sets it apart.